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Background: Genetic susceptibility to diseases is likely influenced by common DNA variants in the form of single nucleotide polymorphisms (SNPs). The value of SNPs for linkage and association mapping studies may depend on the distribution of SNP allele frequencies across populations.Objectives: To establish the SNP allelic frequencies among Caucasian and African American women for tumor necrosis factor...
Induction of a T-helper-type 1 (Th1) immune response is indispensable for successful treatment of superficial bladder cancer with BCG. In this study possible involvement of various cytokines in BCG action as well as their potential roles in enhancing and mimicking BCG effect were explored. In immunocompetent cell cultures, IFN-γ, a major Th1 cytokine, appears to be a late responsive cytokine to BCG...
The secretion of interleukin-6 (IL-6) is modulated by immune, hormonal and metabolic stimuli in a cell-specific manner. We investigated the effect of cytokines, TNFα and IL-1β, and insulin on IL-6 release from human adipocytes and peripheral blood cells (PBC).Adipocytes released IL-6 constitutively (after 5h: 5.64 [1.61-15.30]pgml -1 , after 10h: 15.95 [2.34-45.59]pgml -1 ...
Pretransplant treatment of recipients with recombinant human granulocyte colony-stimulating factor (rhG-CSF, 250μg/kg/day s.c. for 5 days) facilitates heart allograft acceptance in tacrolimus-treated rat recipients. We examined effectiveness of transfusion of in vivo rhG-CSF-treated blood since rhG-CSF induces immunoregulatory cells in human blood. DA heart grafts were transplanted into tacrolimus...
It has been reported that lipopolysaccharide (LPS)-hyporesponsiveness of macrophages (Mφs) of C3H/HeJ mice with a mutated Lps gene (Lps d ) is related to high-level expression of secretory leukocyte protease inhibitor (SLPI) in response to LPS, causing suppression of NF-κB activation and tumor necrosis factor-α (TNF-α) production. We thus examined the effects of SLPI on the TNF-α production...
In recent studies, induction of the heat shock response increased IL-6 production in gut mucosa in vivo and in cultured Caco-2 cells in vitro. The heat shock response is associated with increased survival of cells exposed to otherwise lethal hyperthermia, so called thermotolerance, but the role of IL-6 in the induction of thermotolerance is not known. We tested the hypothesis that treatment of cultured...
We and others have previously shown that leptin has direct effects on the function of monocytes and macrophages. Since obesity is associated with an increased cardiovascular risk, as well as with markedly elevated circulating leptin levels, we examined whether leptin has any pro-inflammatory effects on the function of monocytes.Leptin strongly enhanced the expression and secretion of the interferon-γ-inducible...
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